Mediterranean Chicken Gyros with Creamy Feta Tzatziki

How to make tender Mediterranean chicken gyros with creamy feta tzatziki sauce, fresh vegetables, and warm pita bread in just 45 minutes.

Updated

September 30, 2025

Mediterranean chicken gyros with creamy feta tzatziki sauce and fresh vegetables wrapped in warm pita bread

These Mediterranean chicken gyros bring the best of Greek cuisine straight to your dinner table. I’ll never forget my first authentic gyro from a tiny family-run spot in Denver’s Greek Town back in 2019. The way the warm pita, tangy sauce, and perfectly seasoned chicken came together hooked me instantly.

What makes this recipe work so well for busy weeknights is the simple marinade that packs serious flavor without hours of prep time. The chicken thighs stay incredibly juicy, and that homemade feta tzatziki takes these gyros from good to absolutely restaurant-quality. I’ve made this recipe at least twenty times now, tweaking it until it captured those flavors I remembered.

Ingredients for Mediterranean Chicken Gyros

I always start with quality chicken thighs for this recipe because they stay incredibly juicy and flavorful. Over the years, I’ve found that having all your ingredients prepped and ready makes the whole process smooth and stress-free.

For the Chicken:

  • 1 lb boneless, skinless chicken thighs
  • 1 tablespoon olive oil (I recommend extra virgin for the best flavor)
  • 2 teaspoons dried oregano
  • 1 teaspoon garlic powder
  • ½ teaspoon salt (adjust to taste)
  • ½ teaspoon black pepper (adjust to taste)

For Assembly:

  • 4 pita breads (my preference is whole wheat, but white pita works beautifully too)
  • 1 cup cherry tomatoes, halved
  • 1 cucumber, diced (pro tip: I remove the seeds and let it drain on paper towels for 10 minutes to prevent soggy gyros)
  • 1 red onion, thinly sliced (soak in cold water for 5 minutes to mellow the sharpness)
  • Fresh parsley for garnish

For the Creamy Feta Tzatziki:

  • 1 cup plain Greek yogurt (in my experience, full-fat creates the creamiest texture)
  • ½ cup feta cheese, crumbled
  • 1 tablespoon lemon juice (freshly squeezed works best)
  • 1 clove garlic, minced
  • ¼ teaspoon salt (adjust to taste)
  • ¼ teaspoon black pepper (adjust to taste)

Step-by-Step Instructions

In my experience, the key to perfect gyros is giving that chicken enough time to soak up all those Mediterranean flavors during marinating.

Step 1: Combine the olive oil, dried oregano, garlic powder, salt, and pepper in a medium bowl. Add the chicken thighs and turn to coat every surface evenly. Cover and let marinate for at least 30 minutes at room temperature, or up to 2 hours in the refrigerator for deeper flavor development.

Step 2: While your chicken marinates, prepare the creamy feta tzatziki by mixing together the Greek yogurt, crumbled feta cheese, lemon juice, minced garlic, salt, and pepper until smooth. Cover and refrigerate until ready to serve. This sauce actually tastes even better when the flavors have time to meld together. Use this time to also prep your vegetables: halve the cherry tomatoes, dice the cucumber (remove seeds and let drain on paper towels), and thinly slice the red onion (soak in cold water for 5 minutes, then drain).

Step 3: Heat a skillet over medium-high heat until hot. Add the marinated chicken thighs and cook for 5 to 7 minutes per side until they develop a beautiful golden-brown crust and reach an internal temperature of 165°F. The chicken should feel firm to the touch and release clear juices. If your chicken is browning too quickly on the outside but not cooking through, reduce heat to medium.

Step 4: Transfer the cooked chicken to a cutting board and let it rest for 2 to 3 minutes. This resting period allows the juices to redistribute throughout the meat. Slice the chicken into thin strips against the grain (cutting perpendicular to the muscle fibers) for maximum tenderness.

Step 5: Warm your pita breads in a dry skillet for about 30 seconds per side or wrap them in damp paper towels and microwave for 15 to 20 seconds. Pat the drained cucumber dry with paper towels and drain the soaked red onions.

Step 6: Spread a generous layer of the creamy feta tzatziki across each pita, then arrange the sliced chicken down the center. Top with tomatoes, cucumber, red onion, and fresh parsley. Roll the pita around the fillings and enjoy immediately while everything is warm.

Perfect Pairings for Your Gyros

These Mediterranean chicken gyros pair beautifully with sides that complement their bright, herbaceous flavors and creamy textures.

Greek Salad: A crisp Greek salad with cucumbers, tomatoes, olives, and feta cheese brings refreshing crunch and acidity that balances the rich tzatziki perfectly. The vinegar-based dressing cuts through the richness beautifully.

Crispy Roasted Potatoes: Golden, herb-roasted potatoes seasoned with oregano and lemon zest add satisfying heartiness to your meal while echoing the Mediterranean flavors in the gyros.

Hummus with Warm Pita: Creamy hummus offers additional protein and fiber, making this an even more filling meal. The smooth texture complements the tender chicken wonderfully.

Lemon Rice Pilaf: Fluffy rice cooked with lemon zest, fresh herbs, and a touch of olive oil provides a light, aromatic base that soaks up any extra tzatziki sauce. Try this high-protein turkey pasta with ricotta if you prefer a pasta side instead.

Grilled Vegetables: Zucchini, bell peppers, and eggplant brushed with olive oil and grilled until tender add color, nutrients, and a subtle smokiness that enhances the overall Mediterranean experience.

Keeping Your Gyros Fresh

Store your leftover components separately in airtight containers in the refrigerator for up to 3 days. I recommend keeping the chicken, tzatziki sauce, and fresh vegetables in individual containers to maintain the best texture and flavor.

When you’re ready to enjoy leftovers, gently reheat the sliced chicken in a skillet over medium heat for 2 to 3 minutes, or microwave it for 30 to 45 seconds. Assemble your gyros fresh with cold tzatziki and vegetables for the best taste and texture contrast.

For meal prep purposes, you can marinate and freeze uncooked chicken for up to 3 months. Just thaw it overnight in the refrigerator before cooking. The tzatziki sauce stays fresh for about 3 days, but avoid freezing it as the texture will separate. Pro tip: make a double batch of tzatziki because you’ll want it on everything!

FAQs

Can I use chicken breast instead of chicken thighs?

Absolutely! While chicken thighs stay juicier, boneless chicken breasts work well too. Just reduce the cooking time slightly to 4 to 5 minutes per side and watch the temperature closely to avoid overcooking.

How can I make this recipe gluten-free?

Simply swap regular pita bread for gluten-free pita, or serve the chicken and toppings over rice or in crisp lettuce wraps for a delicious low-carb alternative that’s naturally gluten-free.

Can I prep the tzatziki sauce ahead of time?

Yes! The tzatziki actually tastes better when made a day in advance. The garlic and herbs infuse into the yogurt, creating an even more flavorful sauce. Just store it covered in the refrigerator.

Conclusion

These Mediterranean chicken gyros bring restaurant-quality flavor to your home kitchen with minimal effort and maximum satisfaction. The combination of tender marinated chicken, creamy feta tzatziki, and fresh vegetables creates a meal that’s both nourishing and incredibly delicious. Whether you’re feeding your family on a busy weeknight or impressing guests at a casual gathering, this recipe delivers every single time. Give it a try tonight and discover your new favorite way to enjoy Mediterranean flavors!

Mediterranean chicken gyros with creamy feta tzatziki sauce and fresh vegetables wrapped in warm pita bread

Mediterranean Chicken Gyros with Creamy Feta Tzatziki

Tender marinated chicken thighs wrapped in warm pita bread with fresh vegetables and a rich creamy feta tzatziki sauce. A quick and flavorful Mediterranean dinner ready in 45 minutes.
Prep Time 30 minutes
Cook Time 15 minutes
Total Time 45 minutes
Servings: 4 portions
Course: Dinner, Main Course
Cuisine: Greek, Mediterranean
Calories: 450

Ingredients
  

  • 1 lb boneless, skinless chicken thighs
  • 1 tablespoon olive oil extra virgin recommended
  • 2 teaspoons dried oregano
  • 1 teaspoon garlic powder
  • 0.5 teaspoon salt adjust to taste
  • 0.5 teaspoon black pepper adjust to taste
  • 4 pita breads whole wheat or white
  • 1 cup cherry tomatoes halved
  • 1 cucumber diced, seeds removed, drained
  • 1 red onion thinly sliced, soaked in cold water
  • Fresh parsley for garnish
  • 1 cup plain Greek yogurt full-fat recommended
  • 0.5 cup feta cheese crumbled
  • 1 tablespoon lemon juice freshly squeezed preferred
  • 1 clove garlic minced
  • 0.25 teaspoon salt for tzatziki, adjust to taste
  • 0.25 teaspoon black pepper for tzatziki, adjust to taste

Equipment

  • Mixing bowls
  • Skillet
  • Meat thermometer
  • Knife and cutting board
  • Measuring cups and spoons
  • Paper towels

Method
 

  1. Combine the olive oil, dried oregano, garlic powder, salt, and pepper in a medium bowl. Add chicken thighs and coat evenly. Cover and marinate for at least 30 minutes at room temperature, or up to 2 hours in the refrigerator.
  2. While chicken marinates, prepare the creamy feta tzatziki by mixing Greek yogurt, crumbled feta cheese, lemon juice, minced garlic, salt, and pepper until smooth. Refrigerate until ready to serve. Prep vegetables: halve cherry tomatoes, dice cucumber (remove seeds and drain on paper towels for 10 minutes), and thinly slice red onion (soak in cold water for 5 minutes, then drain).
  3. Heat a skillet over medium-high heat. Add marinated chicken thighs and cook for 5 to 7 minutes per side until golden brown and internal temperature reaches 165°F. If browning too quickly, reduce heat to medium.
  4. Transfer cooked chicken to a cutting board and let rest for 2 to 3 minutes. Slice into thin strips against the grain (perpendicular to muscle fibers) for maximum tenderness.
  5. Warm pita breads in a dry skillet for 30 seconds per side or wrap in damp paper towels and microwave for 15 to 20 seconds. Pat drained cucumber dry with paper towels.
  6. Spread generous amount of creamy feta tzatziki across each pita. Arrange sliced chicken down the center. Top with tomatoes, cucumber, red onion, and fresh parsley. Roll pita around fillings and serve immediately.

Notes

Marinate chicken for at least 30 minutes but preferably up to 2 hours for best flavor. Chicken thighs stay juicier than chicken breasts but either can be used. Store leftovers separately in airtight containers for up to 3 days. The tzatziki sauce can be made a day ahead and tastes even better when flavors meld. For gluten-free option, use gluten-free pita bread or serve in lettuce wraps. Draining cucumber and soaking red onion prevents soggy gyros and mellows the onion’s bite.

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